Patients w/ certain HL at risk for transformation to aggressive lymphoma years later

Patients with certain HL at risk for transformation to aggressive lymphoma years later

HemOnc today
Posted February 4, 2010

The risk for transformation to aggressive lymphoma, commonly diffuse large B-cell lymphoma, was substantial in patients with nodular lymphocyte-predominant Hodgkin’s lymphoma and may occur decades after the original diagnosis.

According to background information in the study, patients with nodular lymphocyte-predominant Hodgkin’s lymphoma (NLPHL) have an inherent tendency to develop secondary non-Hodgkin’s lymphomas. To assess this association at long-term follow-up, researchers searched the British Columbia Cancer Agency Lymphoid Cancer Database and identified 95 patients with NLPHL between 1965 and 2006.

Median age at diagnosis was 37 years. The median follow-up time for living patients was 6.5 years, and the median time to disease transformation was 8.1 years. Fourteen percent of patients experienced transformation to aggressive lymphoma. The median age at the time of transformation was 42 years.


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