Abstract:
One of the first chemotherapy drugs given to patients diagnosed with cancer — especially lung, ovarian, or breast cancer — is cisplatin, a platinum-containing compound that binds to tumor cells' DNA. Cisplatin does a good job of killing those tumor cells, but it can also seriously damage the kidneys, which receive high doses of cisplatin because they filter the blood.
Posted August 9, 2010
Gisselbrecht C. J Clin Oncol. 2010;doi:10.1200/JCO.2010.28.1618.
Rituximab did not improve OS, PFS or event-free survival in patients who relapsed 1 year after a diffuse large B-cell lymphoma diagnosis, according to results from the Collaborative Trial in Relapsed Aggressive Lymphoma study.
For the phase 3, multinational study, researchers in 12 countries randomly assigned 202 patients to rituximab, ifosfamide, etoposide and carboplatin (R-ICE)...
(Reuters) - Oncolytics Biotech Inc (ONC.TO: Quote) (ONCY.O: Quote) said Canadian health regulators approved its plan to conduct late-stage trials for its drug, reolysin, to treat patients with head and neck cancers.
The small Canadian drugmaker said the trial will study the effectiveness of the drug in combination with paclitaxel and carboplatin in patients with head and neck cancers, versus chemotherapy alone.
SOURCE: Peregrine Pharmaceuticals
Jul 14, 2010 08:00 ET
Peregrine Initiates Second Randomized Phase IIb Lung Cancer Trial Using First-In-Class PS-Targeting Monoclonal Antibody Bavituximab
Promising Tumor Response and Median PFS Data Reported at ASCO Lead to New Phase IIb Trial
TUSTIN, CA--(Marketwire - July 14, 2010) - Peregrine Pharmaceuticals, Inc. (NASDAQ: PPHM), a clinical-stage biopharmaceutical company developing first-in-class monoclonal antibodies...
INDIANAPOLIS -- The combination of decitabine and carboplatin appears to improve the outcome of women who have late-stage ovarian cancer. In an upcoming issue of the journal Cancer (online today), Indiana University researchers report four of 10 patients who participated in a phase I clinical trial had no disease progression after six months of treatment. One patient experienced complete resolution of tumor tissue for a period of time.
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