Abstract:
One of the first chemotherapy drugs given to patients diagnosed with cancer — especially lung, ovarian, or breast cancer — is cisplatin, a platinum-containing compound that binds to tumor cells' DNA. Cisplatin does a good job of killing those tumor cells, but it can also seriously damage the kidneys, which receive high doses of cisplatin because they filter the blood.
Tel Aviv University Research on the Mechanism of Copper Transport Into Human Cells may Enhance Chemotherapy
TEL AVIV, Israel, August 9, 2010 /PRNewswire/ -- A new study conducted in the department of Biochemistry and Molecular Biology at Tel Aviv University (TAU) elucidates the way in which toxic, yet essential, copper ions enter human cells. As a chemotherapy drug presumably enters the cells in a similar manner, the results of this study pave the way for the development of improved...
BioVex Announces Publication of Head and Neck Cancer Clinical Trial Results with OncoVEX GM-CSF in the Journal Clinical Cancer Research
WOBURN, Mass. & OXFORD, England--(BUSINESS WIRE)--BioVex Inc, a company developing new generation biologics for the treatment of cancer and prevention of infectious disease, announces that the data from its completed Phase I/II clinical study of OncoVEXGM-CSF for the first line treatment...
Researchers design a new version of cisplatin that spares the kidneys, letting doctors use higher doses.
Anne Trafton, MIT News Office
July 28, 2010
One of the first chemotherapy drugs given to patients diagnosed with cancer — especially lung, ovarian or breast cancer — is cisplatin, a platinum-containing compound that gums up tumor cells’ DNA. Cisplatin does a good job of killing those tumor cells, but it...
For the first time, chemists have isolated selenium-containing quinones and found them to have strong anticancer activity. The new compounds have great potential for future cancer therapy, and early studies show similar activity to the well-known chemotherapy drug cisplatin, although a selenium-based therapy would cost a fraction of the price.
'Selenium or sulfur-containing quinones are not found in nature because they are too unstable,' explains Hani Amouri,...
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