Cyclophosphamide should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Some medical conditions may interact with Cyclophosphamide . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have an infection, chickenpox, a suppressed immune system, bone marrow suppression or other bone marrow problems, low levels of white blood cells or platelets, or liver or kidney problems
• if you have a history of heart disease
• if you are receiving or have received cytotoxic therapy or x-ray or radiation therapy
• if you have had an adrenal gland removed (adrenalectomy)
• if you are receiving or have received chemotherapy or radiation therapy
• if you have unhealed wounds
• if you have to have surgery

Some MEDICINES MAY INTERACT with Cyclophosphamide . Tell your health care provider if you are taking any other medicines, especially any of the following:

• TNF-blocking medicines (eg, etanercept) because the risk of certain types of cancer may be increased
• Doxorubicin or trastuzumab because the risk of heart-related side effects and toxicity may be increased
• Imidazoles (eg, ketoconazole) or phenobarbital because they may increase the risk of Cyclophosphamide 's side effects
• Ondansetron because it may decrease Cyclophosphamide 's effectiveness
• Succinylcholine because its actions and the risk of its side effects may be increased by Cyclophosphamide
• Indomethacin because the risk of its side effects may be increased by Cyclophosphamide
• Digoxin because its effectiveness may be decreased by Cyclophosphamide

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cyclophosphamide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Cyclophosphamide is in the FDA pregnancy category D. This means that cyclophosphamide is known to be harmful to an unborn baby. Cyclophosphamide may also affect egg production in women and sperm production in men. Do not take cyclophosphamide without first talking to your doctor if you are pregnant or could become pregnant during treatment. Use of cyclophosphamide by the father prior to conception has also been associated with birth defects. Contraceptive measures are recommended during treatment with cyclophosphamide for both men and women. Cyclophosphamide passes into breast milk and may harm a nursing infant. Do not take cyclophosphamide without first talking to your doctor if you are breast feeding a baby.